Summary: The first objective of the present proposal is to determine if biological monitoring can add significantly to environmental sampling for CRM-asphalt-specific exposures. The specific aims associated with this objective are: 1. Determine if MIBK is present in any of the personal air-samples, as implied in the EPA summary of four comparative studies. 2. Determine if MIBK, or other constituent exposure measured in the CRM-asphalt but not in the post-shift urine of workers using regular-asphalt or who have no asphalt exposure. 3. Determine if there is an epidemiologic association between the presence of MIBK, or other constituent exposure measured in the personal air samples, and either the personal air-samples or the post-shift urine samples and the presence of self-reported symptoms.
The second of this study is to determine if US road paving workers have biologically relevant exposures to potentially carcinogenic PAH compounds.